Promoting apoptosis as a strategy for cancer drug discovery
β Scribed by Fesik, Stephen W.
- Book ID
- 109947494
- Publisher
- Nature Publishing Group
- Year
- 2005
- Tongue
- English
- Weight
- 608 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1474-1776
- DOI
- 10.1038/nrc1736
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Growing evidence has demonstrated that clonogenic cancer stem (initiating) cells are responsible for tumor regrowth and disease relapse. Bmi-1 plays a critical role in the self-renewal of adult stem cells. The Bmi-1 protein is elevated in many types of cancers, and experimental reduction of Bmi-1 pr
## Abstract Critical processes underlying cancers must be better understood to develop strategies for treatment and prevention. A chemotherapeutic strategy is proposed that is based upon reβestablishment, with a drug, of nullified programmed cell death (apoptosis) in cancer cells, which to survive