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Promoter-specific induction of the phosphatase SHP-1 by viral infection and cytokines in CNS glia

โœ Scribed by George P. Christophi; Chad A. Hudson; Ross Gruber; Christoforos P. Christophi; Paul T. Massa


Book ID
111180828
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
844 KB
Volume
105
Category
Article
ISSN
0022-3042

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We have previously shown that the SH2 domain-containing protein tyrosine phosphatase SHP-1 plays a critical role in controlling virus infection in CNS glia in vivo and in vitro. The present study addressed whether increased virus replication in SHP-1-deficient glia in vitro may be a result of altere