Promoter hypomethylation of protease-activated receptor 2 associated with carcinogenesis in the stomach
β Scribed by Tomiyasu Arisawa; Tomomitsu Tahara; Tomoyuki Shibata; Mitsuo Nagasaka; Masakatsu Nakamura; Yoshio Kamiya; Hiroshi Fujita; Tamaki Takagi; Shin Hasegawa; Fang-Yu Wang; Ichiro Hirata; Hiroshi Nakano
- Book ID
- 108951311
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 214 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0815-9319
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## Abstract ## Objective To investigate whether proteaseβactivated receptor 1 (PARβ1) and/or PARβ2 promotes the invasiveness/proliferation of synovial fibroblasts (SFs) and to determine the signaling mechanisms of these pathways. ## Methods SFs were isolated from the synovial tissue of patients
Gastric ornithine decarboxylase (ODC) activity was measured as a biomarker of tumor-promoting activity in the remnant stomach of rats and humans. Gastrectomy of Wistar rats utilizing the Billroth 1 method caused a significantly high induction of ODC, and use of the Billroth 11 method caused a signif