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Promoter hypermethylation silences cyclooxygenase-2 (Cox-2) and regulates growth of human hepatocellular carcinoma cells

✍ Scribed by Murata, Hiroaki; Tsuji, Shingo; Tsujii, Masahiko; Sakaguchi, Yasuko; Fu, Hai Ying; Kawano, Sunao; Hori, Masatsugu


Book ID
109885761
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
223 KB
Volume
84
Category
Article
ISSN
0023-6837

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Cyclooxygenase (COX)-2 is one of the rate-limiting enzymes in the conversion of arachidonic acid to prostaglandins and other eicosanoids. Recent studies have shown enhanced expression of COX-2 in cancer cells of several tissues. We investigated the expression of COX-2 and prostaglandin (PG) E 2 prod