Promoter hypermethylation of DNA repair gene MGMT in laryngeal squamous cell carcinoma
โ Scribed by Zhang Song; Guo Changkai; Kong Weijia; Liu Zheng
- Publisher
- Springer-Verlag
- Year
- 2006
- Tongue
- Chinese
- Weight
- 564 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0510-9752
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## Abstract O^6^โmethylguanineโDNA methyltransferase (MGMT) is a repair protein that specifically removes promutagenic alkyl groups from the O^6^ position of guanine in DNA. __MGMT__ is transcriptionally silenced by promoter hypermethylation in several human cancers. Methylationโspecific PCR (MSP)