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Promoter CpG hypermethylation and downregulation of DICE1 expression in prostate cancer

✍ Scribed by Röpke, Albrecht; Buhtz, Peter; Böhm, Malte; Seger, Jeannette; Wieland, Ilse; Allhoff, Ernst P; Wieacker, Peter F

Book ID: 110069867
Publisher: Nature Publishing Group
Year: 2005
Tongue: English
Weight: 301 KB
Volume: 24
Category: Article
ISSN: 0950-9232
DOI: 10.1038/sj.onc.1208824

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## Abstract The incidence and mortality of prostate cancer (PC) is approximately 2‐fold higher among African‐Americans as compared to Caucasians and very low in Asian. We hypothesize that inactivation of __GSTP1__ genes through CpG methylation plays a role in the pathogenesis of PC, and its ability