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Prominent Solubilizing Effect of 2-Hydroxypropyl-β-cyclodextrin on a New Thiazolidine Derivative (FPFS-410) with Antidiabetic and Lipid-lowering Activities through Inclusion Complex Formation

✍ Scribed by Takumi Hara; Fumitoshi Hirayama; Hidetoshi Arima; Yoshihiro Yamaguchi; Kaneto Uekama

Publisher
Springer Netherlands
Year
2006
Tongue
English
Weight
260 KB
Volume
56
Category
Article
ISSN
0923-0750

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Enhanced bioavailability of a new thiazo
Enhanced bioavailability of a new thiazolidine derivative FPFS-410, an antidiabetic and lipid-lowering drug, after oral administration of its hydroxypropyl-β-cyclodextrin complex to bile duct-cannulated rats
✍ Takumi Hara; Hidetoshi Arima; Fumitoshi Hirayama; Kaneto Uekama 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 204 KB

The effect of bile acids on bioavailability of FPFS-410 (2-(N-Cyanoimino)-5-{(E)-4-styrylbenzylidene}-4-oxothiazolidine) after oral administration of the drug and its 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CyD) complex was investigated. The complexation with HP-beta-CyD increased the oral bioava