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Prolonged kynurenine 3-hydroxylase inhibition reduces development of levodopa-induced dyskinesias in parkinsonian monkeys

✍ Scribed by Laurent Grégoire; Arash Rassoulpour; Paolo Guidetti; Pershia Samadi; Paul J. Bédard; Emanuela Izzo; Robert Schwarcz; Thérèse Di Paolo

Book ID
116284761
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
366 KB
Volume
186
Category
Article
ISSN
0166-4328

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📜 SIMILAR VOLUMES

Effect of kynurenine 3-hydroxylase inhib
Effect of kynurenine 3-hydroxylase inhibition on the dyskinetic and antiparkinsonian responses to levodopa in parkinsonian monkeys
✍ Pershia Samadi; Laurent Grégoire; Arash Rassoulpour; Paolo Guidetti; Emanuela Iz 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 505 KB

## Abstract Homeostatic interactions between dopamine and glutamate are central to the normal physiology of the basal ganglia. This relationship is altered in Parkinsonism and in levodopa‐induced dyskinesias (LID), resulting in an upregulation of corticostriatal glutamatergic function. Kynurenic ac