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Prolonged Jun N-terminal kinase (JNK) activation and the upregulation of p53 and p21WAF1/CIP1 preceded apoptosis in hepatocytes after partial hepatectomy and cisplatin

✍ Scribed by Kaoru Kobayashi; Ikuyo Tsukamoto

Book ID: 117617826
Publisher: Elsevier Science
Year: 2001
Tongue: English
Weight: 642 KB
Volume: 1537
Category: Article
ISSN: 0925-4439
DOI: 10.1016/s0925-4439(01)00059-x

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## Abstract Protein kinase C (PKC), a family of serine‐threonine kinases, has been implicated in the regulation of colon tumorigenesis. However, the specific isoform of PKC involved in this process is not clear. In the present study, we found that treatment of the cultured human colon cancer cell l