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Prolonged intra-arterial chemotherapy for inoperable cancer: A technique

โœ Scribed by J. L. Tucker Jr.; R. W. Talley

Publisher
John Wiley and Sons
Year
1961
Tongue
English
Weight
275 KB
Volume
14
Category
Article
ISSN
0008-543X

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โœฆ Synopsis

HERE ARE many reports2-8 indicating palli-T ative success in the treatment of inoperable cancers with chemotherapeutic agents administered intra-arterially. They have shown that relief of pain, regression in tumor size, and biopsy evidence of tumor necrosis in the follow-up period can be achieved in some patients by this technique, even though the disease may have been refractory to similar agents given intravenously.

As Sullivan et al. suggested,? localized tumors of the head and neck and of the pelvis and extremities lend themselves to treatment through their arterial blood supply. T h e majority of these reports deal with short-term administration of nitrogen mustard or related agents.

Creech and co-workers,4 as well as others,l have reported the use of alkylating agents by perfusion of an isolated vascular field with bubble oxygenators. T h e success of this method depends on surgical isolation of the vascular supply of the tumor bed so that the

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