𝔖 Bobbio Scriptorium
✦   LIBER   ✦

PROLONGED EXPRESSION OF THE c-kit RECEPTOR IN GERM CELLS OF INTERSEX FETAL TESTES

✍ Scribed by RAJPERT-DE MEYTS, EWA; JØRGENSEN, NIELS; MÜLLER, JØRN; SKAKKEBÆK, NIELS E.

Book ID
101221469
Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
474 KB
Volume
178
Category
Article
ISSN
0022-3417

No coin nor oath required. For personal study only.

✦ Synopsis

Stem cell factor (SCF) and its receptor Kit encoded by the c-kit proto-oncogene are crucial for the development and migration of primordial germ cells in rodents. The expression of Kit has been examined immunohistochemically in gonads obtained from five specimens of fetal tissues with intersex conditions which included 45,X/46,XY mosaicism; androgen insensitivity syndrome; and 46,XY/iso(p)Y mosaicism. Individuals with such disorders of sexual differentiation and Y-chromosome material carry a very high risk of developing testicular neoplasms. Fetal testicular germ cells of the intersex subjects expressed Kit at a later developmental age than controls, in which no Kit protein was detectable beyond the 15th week of gestation. This finding may indicate a disturbance of the chronology of germ cell development, or it may suggest a change of the regulation of c-kit expression in subjects with disorders of gonadal development. KEY woRDs--sex differentiation; testicular development; gonadal dysgenesis; testicular neoplasms; c-kit

📜 SIMILAR VOLUMES

Absence of c-KIT and members of the epid
Absence of c-KIT and members of the epidermal growth factor receptor family in refractory germ cell cancer
✍ C. Kollmannsberger; F. Mayer; H. Pressler; S. Koch; L. Kanz; J. W. Oosterhuis; L 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 871 KB

## Abstract ## BACKGROUND Germ cell tumors (GCTs) in adolescent and young males are very sensitive to cisplatin‐based chemotherapy. However, 10–20% of the patients cannot be cured by currently available therapeutic options. Once a tumor does not respond to cisplatin, current therapeutic modalities

Sertoli cells in testes containing or la
Sertoli cells in testes containing or lacking germ cells: A comparative study of paracrine effects using the W (c-kit) gene mutant mouse model
✍ Renato De França, Luiz ;Bartke, Andrzej ;Borg, Kurt E. ;Oecim, Marcelo ;Fadden, 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 988 KB

## Abstract __Background__: Paracrine effects of germ cells on Sertoli cell structure were examined in a mouse model with the W locus (dominant white spotting) mutation in which animals with the W/W^v^ genotype (referred to as mutants) lack virtually all germ cells. __Results__: Morphometric deter