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Prolonged endoplasmic reticulum stress promotes mislocalization of immunoglobulins to the cytoplasm

โœ Scribed by Adi Drori; Shahram Misaghi; Joseph Haimovich; Martin Messerle; Boaz Tirosh

Book ID
116757667
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
758 KB
Volume
47
Category
Article
ISSN
0161-5890

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The unfolded protein response (UPR) is an evolutionarily conserved cell signaling pathway that is activated to regulate protein synthesis and restore homeostatic equilibrium when the cell is stressed from increased client protein load or the accumulation of unfolded or malfolded proteins. Once activ