Prolonged alteration in composition of fast transported protein in axons prevented from regenerating after injury
✍ Scribed by Bisby, M. A.
- Publisher
- John Wiley and Sons
- Year
- 1982
- Tongue
- English
- Weight
- 487 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0022-3034
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✦ Synopsis
A previous study revealed a characteristic alteration in the ratio of labeling of two fast axonally transported polypeptides identified as S1 (22,000 daltons) and S: ! (18,000 daltons) and their ratio (Sz/S1) in rat motoneuron axons following axonal injury and subsequent regeneration. In this study the S2/S1 ratio was determined for axons which were resected and ligated proximally and which did not regenerate to reinnervate muscle. While the initial increase in the SJS1 ratio following section was the same as that following a crush, the Sz/S1 ratio did not return towards normal values after 42 days, but remained elevated for at least 98 days after injury. It is concluded that the return of S2/S1 ratio to normal values, like some other manifestations of the cell body reaction, is delayed if the injured axons do not regenerate.