Prolongation of rat heart allograft survival with K+ATP-dependent channel modulators
✍ Scribed by Dominic Rheaume; Louis Dumont; Junzheng Peng; Dasheng Xu; Shijie Qi; Dingyi Liu; Huifang Chen
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 36 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0738-1085
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✦ Synopsis
Controversies exist regarding the immunoregulatory properties of K + ATP channel modulators. We investigated the effects of aprikalim, a K + ATP-dependent channels activator, and glibenclamide and gliclazide, two inhibitors of K + ATPdependent channels, on the prolongation of heart allograft survival in the rat. Nine groups (n Ն 5) were involved in this study with the Brown-Norway to Lewis rat combination treated with aprikalim, glibenclamide, gliclazide, and/or cy-closporine. The results indicate that modulators of K + ATPdependent channels can improve the survival of rat heart allograft without interfering with the immunosuppressive properties of cyclosporine.