𝔖 Bobbio Scriptorium
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Proline kinks in transmembrane α-helices

✍ Scribed by Gunnar von Heijne


Book ID
118918987
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
473 KB
Volume
218
Category
Article
ISSN
0022-2836

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Proline-induced constraints in α-helices
✍ Lucjan Piela; George Némethy; Harold A. Scheraga 📂 Article 📅 1987 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 758 KB

The disrupting effect of a prolyl residue on an a-helix has been analyzed by means of conformational energy computations. In the preferred, nearly a-helical conformations of Ac-Ala,-Pro-NHMe and of Ac-Ala7-Pro-Ah7-NHMe, only the residue preceding Pro is not a-helical, while all other residues can oc