✍ Scribed by Bin Yang; Junde Dong; Xuefeng Zhou; Xianwen Yang; Kyung Jin Lee; Lishu Wang; Si Zhang; Yonghong Liu
No coin nor oath required. For personal study only.
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A detailed analysis of the chemical constituents of a marine sponge of Callyspongia sp. was performed. A new proline‐containing dipeptide, callyspongidipeptide A (cyclo__‐((S)‐Pro‐8‐hydroxy‐__(R)‐Ile); 1) along with cyclo‐((S)‐Pro‐(R)‐Leu) (3) and seco‐((S)‐Pro‐(R)‐Val) (2) were isolated. The structures were determined on the basis of NMR and MS analysis, and the absolute configuration was determined by comparison of the optical rotation with known compounds.
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Akateapin (1) , m inhibitor of phosphatidylinositol-specific phospholipase C, w~ isolated from ma acetone e~tract of the marine Slxmge, Callyspongia sp. Structural determination by 2D-NMR speclroscopy revealed that it was a novel triteq~ene with the hydmquimme disulfats.
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The unidentified configurations at C 5 and C10 in callystatin A (1), a potent cytotoxic polyketide from the marine sponge Callyspongia truncata, were determined to be R, R by comparing the circular dichroism spectrum of 1 with those of two model compounds 2 and 3. Compounds 2 and 3 were synthesized