Synthesis and biological activity of P2–
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J.Edward Semple; David C. Rowley; Terence K. Brunck; William C. Ripka
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Article
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1997
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Elsevier Science
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English
⚖ 388 KB
Molecular modeling and topographic considerations of the thrombin-specific sequences Boc-Asp-Pro-Arg-TS or Ac-d-Phe-Pro-Arg-TS (TS = transition state analog electrophilic center) and related scaffolds led to the design of novel P2-P4-azapeptidomimetic Pl-argininal and Pl-ketoargininamide derivatives