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Proliferative effects of several hematopoietic growth factors on acute myelogenous leukemia cells and correlation with treatment outcome

✍ Scribed by Tsuzuki, M; Ezaki, K; Maruyama, F; Ino, T; Kojima, H; Okamoto, M; Yamaguchi, T; Nomura, T; Miyazaki, H; Wakita, M

Book ID: 110053703
Publisher: Nature Publishing Group
Year: 1997
Tongue: English
Weight: 125 KB
Volume: 11
Category: Article
ISSN: 0887-6924
DOI: 10.1038/sj.leu.2400870

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GM-CSF is a major regulator of myelopoiesis. Recombinant human GM-CSF (250 micrograms/m2 per day i.v.) was used prior to chemotherapy ("3 + 7" scheme) to recruit leukemic blasts in vivo (de novo AML patients, n = 20) into the chemotherapy sensitive phases of the cell cycle. The stimulatory effect of