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Prolactin Stimulates Mitogen-Activated Protein Kinase in Human Leiomyoma Cells

✍ Scribed by Ataru Nohara; Masahide Ohmichi; Koji Koike; Hiroaki Jikihara; Akiko Kimura; Kanji Masuhara; Hiromasa Ikegami; Masaki Inoue; Akira Miyake; Yuji Murata

Book ID: 115580888
Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 254 KB
Volume: 238
Category: Article
ISSN: 0006-291X
DOI: 10.1006/bbrc.1997.7322

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In these experiments we tested the hypothesis that constitutive activation of polyamine(PA) biosynthesis may contribute to mammary carcinogenesis. Spontaneously immortalized normal human MCF-10A breast epithelial cells were infected with the retroviral vector pLOSN containing a cDNA which codes for