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Prolactin secretion in permeable GH3 pituitary cells is stimulated by Ca2+ and protein kinase C activators

✍ Scribed by S.A. Ronning; T.F.J. Martin

Book ID: 115758462
Publisher: Elsevier Science
Year: 1985
Tongue: English
Weight: 502 KB
Volume: 130
Category: Article
ISSN: 0006-291X
DOI: 10.1016/0006-291x(85)90448-6

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## Abstract The effects of rottlerin, a known inhibitor of protein kinase C‐δ activation, on ion currents were investigated in pituitary tumor (GH~3~) cells. Rottlerin (0.3–100 µM) increased the amplitude of Ca^2+^‐activated K^+^ current (I~K(Ca)~) in a concentration‐dependent manner with an EC~50~