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Progressive tumor features accompany epithelial–mesenchymal transition induced in mitochondrial DNA–depleted cells

✍ Scribed by Akihiro Naito; Cody C. Cook; Takatsugu Mizumachi; Mian Wang; Cheng-hui Xie; Teresa T. Evans; Thomas Kelly; Masahiro Higuchi


Book ID
108584261
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
239 KB
Volume
99
Category
Article
ISSN
1347-9032

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## Abstract Constitutive activation of the MAP kinase kinase MEK1 induces oncogenic transformation in intestinal epithelial cells. Loss of cell–cell adhesion followed by the dissociation of epithelial structures is a prerequisite for increased cell motility and tumor invasion. This phenotypic switc