Tomaculous neuropathy is the descriptive term for the "sausagelike" swellings of myelin characteristic of hereditary neuropathy with liability to pressure palsies (HNPP). A 1.5-Mb deletion in chromosome 17pl1.2 is present in the majority but not all cases of HNPP. We reviewed the clinical and electr
Progressive sensory neuropathy in patients without carcinoma: A disorder with distinctive clinical and electrophysiological findings
β Scribed by Dr. Michael D. Kaufman; Linton C. Hopkins; Barrie J. Hurwitz
- Publisher
- John Wiley and Sons
- Year
- 1981
- Tongue
- English
- Weight
- 601 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0364-5134
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β¦ Synopsis
Abstract
Seven patients with severe progressive impairment of kinesthetic sense, mild dysfunction of cutaneous sense, and sparing of motor function were examined during a 3βyear period. The clinical and electrophysiological findings are described in detail. None of these seven has had evidence of cancer despite a thorough investigation and a 3β to 16βyear (average, 7 years) period of symptoms. These patients' symptoms were indistinguishable from those of patients with sensory neuropathy and coexistent carcinoma, suggesting that progressive sensory neuropathy is not invariably associated with carcinoma.
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