✦ LIBER ✦

Progressive neurological disease associated with chronic cytomegalovirus infection

✍ Scribed by Dr. Patrick F. Bray; James F. Bale; Robert E. Anderson; Earl R. Kern

Publisher: John Wiley and Sons
Year: 1981
Tongue: English
Weight: 501 KB
Volume: 9
Category: Article
ISSN: 0364-5134
DOI: 10.1002/ana.410090513

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Cytomegalovirus (CMV), the most common infectious cause of nervous system damage in the fetus and newborn infant, generally has been thought to exert its teratogenic effect during early pregnancy, and it has been assumed that clinical or postmortem abnormalities reflect static insults incurred earlier. Over the past two years we have identified two infants who presented with various clinical signs suggesting CMV infection. Serial CT head scans showed mild hydrocephalus progressing to extensive loss of brain substance and hydrocephalus in one and a normal scan going on to polycystic encephalomalacia in the other. Both infants had urine or leukocyte cultures that were repeatedly positive for CMV. These data suggest that CMV can cause progressive central nervous system damage after birth. The findings may account for some unexplained brain malformations and for a portion of the neurodegenerative disorders occurring in babies who appear normal at birth.

📜 SIMILAR VOLUMES

Ross syndrome associated with cytomegalo

Ross syndrome associated with cytomegalovirus infection

✍ Yuriko Nagane; Kimiaki Utsugisawa 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 134 KB

Antibody response to cytomegalovirus: A

Antibody response to cytomegalovirus: A comparison between adult patients with neurological disease and uncomplicated infection

✍ Dr. Marta Granstrom; Annika Linde; Britta Wahren 📂 Article 📅 1981 🏛 John Wiley and Sons 🌐 English ⚖ 463 KB

## Abstract Cytomegalovirus (CMV) infection in adults can cause neurological diseases such as the Guillain—Barré syndrome (GBS) and myelitis. The mechanism leading to the development of neurological damage is, however, still unknown. We have investigated the possibility that an abnormal humoral imm

Factors associated with primary cytomega

Factors associated with primary cytomegalovirus infection during pregnancy

✍ Sergio Stagno; Gretchen Cloud; Robert F. Pass; William J. Britt; Charles A. Alfo 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 English ⚖ 430 KB

We compared a group of 40 susceptible pregnant women who acquired CMV during gestation with a group of 86 women of similar race and socioeconomic background who remained seronegative to define factors associated with the risk of CMV infection during pregnancy. A logistic regression model using a ste

Transient ischemic attack associated wit

Transient ischemic attack associated with acute cytomegalovirus infection

✍ Sharon Amit; Avi Gadoth; Michael Giladi; Dan Justo 📂 Article 📅 2012 🏛 John Wiley and Sons 🌐 English ⚖ 51 KB

## Abstract Acute cytomegalovirus (CMV) infection is associated with thromboembolism. However, cerebrovascular ischemic events have not been reported in relation to acute CMV infection. A patient with a transient ischemic attack and acute CMV infection is described. Transient appearance of anti‐pho

Keratin variants associate with progress

Keratin variants associate with progression of fibrosis during chronic hepatitis C infection

✍ Pavel Strnad; Tim C. Lienau; Guo-Zhong Tao; Laura C. Lazzeroni; Felix Stickel; D 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 845 KB

Keratins 8 and 18 (K8/K18) protect the liver from various forms of injury. Studies of liver explants from a large cohort of U.S. patients showed that K8/K18 mutations confer a risk to developing end-stage liver diseases, though which diseases are preferentially involved is unknown. We tested the hyp

Mannose binding lectin gene mutations ar

Mannose binding lectin gene mutations are associated with progression of liver disease in chronic hepatitis B infection

✍ Man-Fung Yuen; Chak-Sing Lau; Yu-Lung Lau; Wai-Man Wong; Chi-Chung Cheng; Ching- 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 77 KB 👁 1 views

Mannose-binding lectin (MBL) plays an important role in immune defense. We examined the MBL gene mutations and MBL levels in Chinese hepatitis B and hepatitis C patients with and without symptomatic cirrhosis. We recruited 190 hepatitis B and C patients, and 117 normal Chinese as controls. Serum MBL