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Progressive dementia with ‘diffuse Lewy-type inclusions’ in cerebral cortex

✍ Scribed by Kenji Ikeda; Akira Hori; Gerd Bode

Publisher: Springer-Verlag
Year: 1980
Tongue: English
Weight: 615 KB
Volume: 228
Category: Article
ISSN: 1433-8491
DOI: 10.1007/bf00342349

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✦ Synopsis

A 69-year-old male suffering from progressive dementia died 3 years after the beginning of his disease. The neuropathology of this case revealed the coexistence of senile changes, typical for Alzheimer's disease, and the characteristics of Parkinson's disease, namely, numerous senile plaques and neurofibrillary tangles in the cerebrum and neuronal loss with depigmentation in the substantia nigra and locus caeruleus. Lewy-type inclusions were distributed not only in the pigmented brain stem nuclei, but also diffusely in the CNS. The close nosological relationship between paralysis agitans and Alzheimer's disease is discussed.

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Five cases of age range 62-72 years with progressive dementia and muscular rigidity are reported and discussed from the clinicopathologic point of view. The neuropathology of these cases was characterized by the widespread occurrence of Lewy bodies (LB) in the CNS as well as the presence of senile c