Progression of metastatic human prostate cancer to androgen independence in immunodeficient SCID mice
โ Scribed by Klein, Karen A.; Reiter, Robert E.; Redula, James; Moradi, Hamid; Zhu, Xaio Lin; Brothman, Arthur R.; Lamb, Dolores J.; Marcelli, Marco; Belldegrun, Arie; Witte, Owen N.
- Book ID
- 109928166
- Publisher
- Nature Publishing Group
- Year
- 1997
- Tongue
- English
- Weight
- 809 KB
- Volume
- 3
- Category
- Article
- ISSN
- 1078-8956
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract Despite earlier detection and recent advances in surgery and radiation, prostate cancer is second only to lung cancer in male cancer deaths in the United States. Hormone therapy in the form of medical or surgical castration remains the mainstay of systemic treatment in prostate cancer.
## BACKGROUND. Most prostate cancer cells respond to initial hormonal therapy; however, some of them eventually acquire resistance to the hormonal therapy. Hormone-independent prostate cancer usually exhibits resistance to chemotherapy and radiotherapy. Antioxidant systems are known to be involved