## Background: The protein eukaryotic initiation factor 4e (elf4e) binds to messenger ribonucleic acid (mrna) as the initial step in protein synthesis. overexpression of elf4e results in upregulation of specific proteins essential to cell growth and division. overexpression of elf4e has been found
Progression of eIF4E gene amplification and overexpression in benign and malignant tumors of the head and neck
β Scribed by M. Scott Haydon; J. David Googe; Donald S. Sorrells; G. E. Ghali; Benjamin D. L. Li
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 132 KB
- Volume
- 88
- Category
- Article
- ISSN
- 0008-543X
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Background: Abnormalities of chromosome band 11q13 are frequent in squamous cell carcinoma of the head and neck (scchn). the oncogene ccnd1 is located at 11q13 and encodes cyclin d1, a cell cycle-regulating protein. the authors investigated the clinical relevance and associations between amplifi
Persistent liver nodules (PNs) and hepatocellular carcinomas (HCCs) induced in F344 rats by the resistant hepatocyte (RH) model exhibit c-myc overexpression and amplification. The role of these changes in progression of PN was investigated in nodules with different propensities to evolve to HCC in r
The candidate tumor-suppressor gene ING1 encodes p33 ING1 , a nuclear protein which physically interacts with TP53. It has been shown that p33 ING1 acts in the same biochemical pathway as TP53, leading to cell growth inhibition. Interestingly, a rearrangement of the ING1 gene was found in a neurobla