Progression of age-associated cognitive impairment correlates with quantitative and qualitative loss of TrkA receptor protein in nucleus basalis and cortex

Loss of nucleus basalis neurons containi

Loss of nucleus basalis neurons containing trkA immunoreactivity in individuals with mild cognitive impairment and early Alzheimer's disease

✍ Elliott J. Mufson; Shuang Y. Ma; Elizabeth J. Cochran; David A. Bennett; Laural 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 323 KB 👁 2 views

Recent studies indicate that there is a marked reduction in trkA-containing nucleus basalis neurons in end-stage Alzheimer's disease (AD). We used unbiased stereological counting procedures to determine whether these changes extend to individuals with mild cognitive impairment (MCI) without dementia