✦ LIBER ✦

Progress toward the development of agents to modulate the cell cycle

✍ Scribed by Peter L Toogood

Book ID: 104414682
Publisher: Elsevier Science
Year: 2002
Tongue: English
Weight: 101 KB
Volume: 6
Category: Article
ISSN: 1367-5931
DOI: 10.1016/s1367-5931(02)00342-3

No coin nor oath required. For personal study only.

✦ Synopsis

With taxanes continuing to prove useful in the clinical treatment of cancer, the next generation of antimitotic agents has entered clinical trials. Other mechanisms awaiting proof-of-concept for the treatment of antiproliferative diseases include inhibition of cyclin-dependent kinases (Cdks). Flavopiridol and UCN-01 are continuing in clinical trials, and newer more selective Cdk inhibitors are now entering clinical evaluation.

📜 SIMILAR VOLUMES

The contribution of cell cycle regulatio

The contribution of cell cycle regulation to endosperm development

✍ Sabelli, Paolo A. ;Larkins, Brian A. 📂 Article 📅 2009 🏛 Springer 🌐 English ⚖ 469 KB

Towards a blueprint of the cell cycle

✍ Alberghina, Lilia; Porro, Danilo; Cazzador, Lorenzo 📂 Article 📅 2001 🏛 Nature Publishing Group 🌐 English ⚖ 181 KB

Modulation of the nuclear antigen p105 a

Modulation of the nuclear antigen p105 as a function of cell-cycle progression

✍ Charles V. Clevenger; Alan L. Epstein; Kenneth D. Bauer 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 English ⚖ 1005 KB

1987 ALAN R. LISS. INC 'Upper values represent mean gold particles per fim2 SEM, n = 3 groups of 20 cells each. < 1 colloid gold particle/fim2 was observed over the cytoplasm and extracellular space. Lower values (parenthesis) represent the summed total of gold $CM sorted on the basis of anti-pl05 i

Progress toward the development of a via

Progress toward the development of a viable BACE-1 inhibitor

✍ Shawn J. Stachel 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 132 KB

Modulation of fibroblast response to mai

Modulation of fibroblast response to maitotoxin along the cell division cycle

✍ J. Berreur-Bonnenfant; M. Ammar; A. Dubreuil; H. Kiefer; G Diogene; P. Metezeau; 📂 Article 📅 1994 🏛 Springer 🌐 English ⚖ 352 KB

Drosophila development pulls the strings

Drosophila development pulls the strings of the cell cycle

✍ Bruce H. Reed 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 466 KB 👁 3 views

The three cycles of cell division immediately following the formation of the cellular blastoderm during Drosophila embryogenesis display an invariant pattern('?\*). Bursts of transcription of a gene called string are required and sufficient to trigger mitosis at this time during de~elopment(~). The