Efforts to develop therapeutically relevant HIV protease inhibitors as medicinal agents in confronting the AIDS crisis have been aided by the wealth of fundamental information acquired during related drug discovery campaigns against other aspartyl proteases. This knowledge base was brought to full f
Progress in the discovery of orally bioavailable inhibitors of HIV protease
β Scribed by Dale J. Kempf
- Book ID
- 105481377
- Publisher
- Springer
- Year
- 1995
- Tongue
- English
- Weight
- 618 KB
- Volume
- 2
- Category
- Article
- ISSN
- 0928-2866
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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a βFull Textβ option. The original article is trackable v
Several small, achiral nonpeptide inhibitors of HIV-1 protease with low micromolar activity were identified by mass screening of the Parke-Davis compound library. Two of the compounds, structurally similar, were both found to be competitive and reversible inhibitors [compound 1, 4-hydroxy-3-(3-pheno