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Progress in medicinal chemistry, Vol. 12. Edited by G. P. Ellis and G. B. West. American Elsevier, 52 Vanderbilt Avenue, New York, NY 100017, 1975. 484 pp. 15.5 × 21.5 cm. Price $58.50

✍ Scribed by Charles M. Darling

Publisher: John Wiley and Sons
Year: 1976
Tongue: English
Weight: 131 KB
Volume: 65
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.2600651046

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The integral in Eq. 15 was evaluated numerically by a commonly used integration algorithm (4). Special caution must be taken in applying a loading dose of a nonlinear drug. It may not be desirable to use a loading dose for a drug showing a narrow therapeutic index. However, in certain clinical situ