[Progress in Drug Research] Advances in Targeted Cancer Therapy Volume 63 || Preclinical development of Alimta™ (Pemetrexed, LY231514), a multitargeted antifolate
✍ Scribed by Herrling, Paul L.; Matter, Alex; Schultz, Richard M.
- Book ID
- 124050693
- Publisher
- Birkhäuser-Verlag
- Year
- 2005
- Tongue
- German
- Weight
- 172 KB
- Edition
- 2005
- Category
- Article
- ISBN-13
- 9783764371746
No coin nor oath required. For personal study only.
✦ Synopsis
This volume is the first book to cover the general topic of targeted cancer therapy. It presents a range of targets such as tumor angiogenesis, cell cycle control and cell signalling, COX-2, apoptosis/cell survival, invasion and metastasis and approaches like kinase inhibitors, antisense, and antibody-based therapeutics. The emphasis is on preclinical development, including target validation, development of biomarkers, strategies for combination approaches, and development of resistance. The particular challenges involved in translating these data to clinical application are discussed.
This volume should be of broad general interest to researchers and clinicians involved in cancer therapy as well as other scientists interested in current strategies for cancer treatment.