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Progress in Depsipeptide-Based Biomaterials

✍ Scribed by Yakai Feng; Jian Lu; Marc Behl; Andreas Lendlein

Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 298 KB
Volume: 10
Category: Article
ISSN: 1616-5187
DOI: 10.1002/mabi.201000076

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✦ Synopsis

Abstract

Polydepsipeptides – alternating copolymers of an α‐amino acid and an α‐hydroxy acid – are a group of biodegradable polymers. Versatile polydepsipeptides with or without pendant functional groups, as well as various polymer architectures, for example, providing alternative, random, diblock, triblock, multiblock or graft sequence structures, can be synthesized via ring‐opening copolymerization of various morpholine‐2,5‐dione derivatives. They are potential candidates for a wide range of biomedical applications. Polydepsipeptides are described in this review from the aspect of materials science, especially as biomaterials. We mainly focus on various techniques developed to synthesize polydepsipeptides and their copolymers, biodegradation behaviors, shape‐memory properties and possible biomedical applications.

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