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Progranulin mutation causes frontotemporal dementia in the Swedish Karolinska family

✍ Scribed by Huei-Hsin Chiang; Lina Rosvall; Jesper Brohede; Karin Axelman; Behnosh F. Björk; Inger Nennesmo; Tiina Robins; Caroline Graff


Book ID
118464572
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
696 KB
Volume
4
Category
Article
ISSN
1552-5260

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Progranulin null mutations in both spora
✍ Isabelle Le Ber; Julie van der Zee; Didier Hannequin; Ilse Gijselinck; Dominique 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 355 KB

Frontotemporal dementia (FTD) is the second most frequent type of neurodegenerative dementias. Mutations in the progranulin gene (GRN, PGRN) were recently identified in FTDU-17, an FTD subtype characterized by ubiquitin-immunoreactive inclusions and linkage to chromosome 17q21. We looked for PGRN mu