Programmed cell death in procyclic Trypanosoma brucei rhodesiense is associated with differential expression of mRNAs

Exacerbated tissue destruction in DSS-in

Exacerbated tissue destruction in DSS-induced acute colitis of OPN-null mice is associated with downregulation of TNF-α expression and non-programmed cell death

✍ Andre Paes Batista da Silva; Aaron Pollett; Susan R. Rittling; David T. Denhardt 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 552 KB

## Abstract Osteopontin (OPN), a pro‐inflammatory mediator, is constitutively expressed in normal gut and is upregulated in inflammatory colitis. To determine the significance of OPN in inflammatory bowel disease, we studied the development of acute, experimental colitis induced by dextran sulfate