✦ LIBER ✦
Programmable one-pot synthesis of tumor-associated carbohydrate antigens Lewis X dimer and KH-1 epitopes
✍ Scribed by Bin-Ling Tsai; Jeng-Liang Han; Chien-Tai Ren; Chung-Yi Wu; Chi-Huey Wong
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- French
- Weight
- 531 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
The total synthesis of the antigenic Lewis X (Le x ) dimer and KH-1 epitopes by a reactivity-based programmable one-pot synthetic strategy is reported. This approach can minimize the protection-deprotection and purification steps. Using the reactivity-based one-pot synthetic method, the fully protected Lewis X (Le x ) dimer and KH-1 epitopes were furnished in a facile manner, which were globally deprotected to give the Le x dimer and KH-1 epitopes.