Prognostic value of tumour-infiltrating lymphocytes (TILs) in colorectal cancer

✍ Scribed by Ropponen, Kirsi M.; Eskelinen, Matti J.; Lipponen, Pertti K.; Alhava, Esko; Kosma, Veli-Matti

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 181 KB
• Volume: 182
• Category: Article
• ISSN: 0022-3417
• DOI: 10.1002/(sici)1096-9896(199707)182:3<318::aid-path862>3.0.co;2-6

✦ Synopsis

Clinical follow-up data of 276 colorectal adenocarcinoma patients treated in Kuopio University Hospital between 1976 and 1986 and followed up for a mean of 14 years were analysed. The clinical findings were correlated with tumour-infiltrating lymphocytes (TILs) and with histological and quantitative factors including nuclear parameters and volume-corrected mitotic index. In univariate survival analysis, TNM classification, Dukes' stage, histological grade, and TILs were significant predictors of survival. TNM classification, Dukes' stage, and TILs also predicted recurrence-free survival. In multivariate analysis, TILs were an independent prognostic factor of survival in all cases, as well as in patients with T1-4N0-3M0 and T1-4N1-3M1. TILs also independently predicted recurrence-free survival. TILs can provide important prognostic information in colorectal cancer to be used in evaluating for adjuvant therapy in different tumour stages.