Prognostic value of total cathepsin D in breast tumors
✍ Scribed by Moïse Namer; Alain Ramaioli; Xavier Fontana; Marie-Christine Etienne; Michel Héry; Alain Jourlait; Gérard Milano; Marc Frenay; Eric François; Françoise Lapalus
- Book ID
- 105425498
- Publisher
- Springer US
- Year
- 1991
- Tongue
- English
- Weight
- 739 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0167-6806
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Background. Cathepsin D is a lysosomal protease overexpressed and abnormally secreted in most breast cancer cells. Several retrospective clinical studies have shown that cathepsin D is an independent prognostic factor in breast cancer that is associated with a higher risk of recurrence and a shorter
Total tumor cathepsin D (TCD) levels were determined prospectively by a radioimmunometric assay in tumor c y t o d of 858 primary breast cancer patients diagnosed between 1989-1991. In 581 of these patients, tumor HER-l/neu oncogene amplification was simultaneously determined. In a "traininset" of 3