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Prognostic Value of Proliferation Index and Expression of the RNA Component of Human Telomerase (hTR) in Papillary Meningiomas

โœ Scribed by Elisabeth J. Rushing; Sarah M. Colvin; Adi Gazdar; Norimasa Miura; Charles L. White; Caetano Coimbra; Dennis K. Burns


Book ID
110234547
Publisher
Springer US
Year
1999
Tongue
English
Weight
120 KB
Volume
45
Category
Article
ISSN
0167-594X

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Telomerase is a ribonucleoprotein that synthesizes telomeric DNA on chromosomal ends. While telomerase is undetectable in most normal somatic tissues, telomerase activation has been detected by a polymerase chain reaction (PCR)-based assay (TRAP) in many immortal cell lines and various cancers, incl

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## BACKGROUND. The enzyme telomerase is associated with cellular immortality and is expressed in the vast majority of human neoplasms. The expression of the RNA component of human telomerase (hTR) shows excellent concordance with enzyme activity. ## METHODS. In this study, hTR expression was an

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## BACKGROUND. During human development, telomerase is repressed in most somatic cells, whereas it is maintained in male germline cells. Reactivation of telomerase has been associated with somatic cancers. To the authors' knowledge, the role of telomerase in germ cell derived malignancies has not