Prognostic value of preoperative immunosuppressive acidic protein in patients with gastric carcinoma: Findings from three independent clinical trials
✍ Scribed by Junichi Sakamoto; Satoshi Teramukai; Akihiko Koike; Shigetoyo Saji; Yasuo Ohashi; Hiroaki Nakazato; Tumor Marker Committee for the Study Group of Immunochemotherapy with PSK for Gastric Cancer
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 534 KB
- Volume
- 77
- Category
- Article
- ISSN
- 0008-543X
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✦ Synopsis
Immunosuppressive acidic protein (UP) has been reported to have close correlation with the impairment of host immune response. To evaluate the significance of LAP in clinical studies, the prognostic value of preoperative IAP was investigated in clinical trials of patients with gastric carcinoma after curative resection.
METHODS. An appropriate IAP threshold value of 580 pglmL was determined using Cox's proportional hazards model. Five-year survival rates were estimated for high and low IAP groups in three different clinical studies. Meta-analysis was performed based on individual patient data, and summarized hazard ratios were estimated using a stratified proportional hazards model.
RESULTS.
Meta-analysis of the three clinical trials demonstrated that patients with preoperative IAP levels above the threshold had significantly poorer cancer related survival ( P = 0.0039) and absolute survival ( P = 0.00231, even after adjustment for the major prognostic factors.
CONCLUSIONS.
Gastric carcinoma patients with an IAP value above the threshold level of 580 pg/mL have a higher risk of cancer death and absolute death than patients with an IAP value below the threshold value. Cancer 1996; 722206-12.