Prognostic value of paranasopharyngeal extension of nasopharyngeal carcinoma: A significant factor in local control and distant metastasis

✍ Scribed by Daniel T. T. Chua; Jonathan S. T. Sham; Dora L. W. Kwong; Damon T. K. Choy; Gordon K. H. Au; P. M. Wu

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 683 KB
• Volume: 78
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/(sici)1097-0142(19960715)78:2<202::aid-cncr3>3.0.co;2-n

✦ Synopsis

BACKGROUND.

This study was conducted to evaluate the prognostic value of paranasopharyngeal extension in local control and distant metastasis in patients with nasopharyngeal carcinoma.

METHODS.

Three hundred and sixty-four patients with newly diagnosed nasopharyngeal carcinoma without distant metastasis were reviewed. Patients were staged according to Ho's staging system. Using a semiquantitative method, tumor extension into the paranasopharyngeal space was graded as: 0: no extension; 1:-extension to the retrostyloid space; 2:-extension to the prestyloid space; and 3:-extension to the anterior part of the masticator space. All patients received radiotherapy as primary treatment. Median follow-up time was 45 months (range, 4.7 to 76.5 months). Relapse free, local relapse free, and distant metastasis free survival were estimated using the Kaplan-Meier method. Cox regression was also performed to adjust for prognostic factors.