Prognostic Value of Laurén Classification and c-erbB-2 Oncogene Overexpression in Adenocarcinoma of the Esophagus and Gastroesophageal Junction
✍ Scribed by W. Polkowski; J. W. van Sandick; G. J. A. Offerhaus; F. J. W. ten Kate; J. Mulder; H. Obertop; J. J. B. van Lanschot
- Publisher
- Springer
- Year
- 1999
- Tongue
- English
- Weight
- 140 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1068-9265
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## Background: The c-erbb-2 gene codes for a putative transmembrane protein, similar in structure to the epidermal growth factor receptor. amplification and/or overexpression of the gene has been recently described with a prognostic significance in a variety of human adenocarcinomas. ## Methods:
It is well established that the activation of proto-oncogenes could trigger uncontrolled cell growth and cancer development. Although this correlation has already been evidenced in several human tumors, no conclusive studies have related oncogene activation with the development of prostatic neoplasi