## BACKGROUND. The prognosis for patients with renal cell carcinoma depends mainly on pathological stage and grade of the tumor at the time of surgery. Cellular proliferation may prove to be another measure for predicting biologic aggressiveness and, therefore, the prognosis. ## METHODS. The au
Prognostic value of karyometric and clinical characteristics in renal cell carcinoma quantitative assessment of tumor heterogeneity
β Scribed by Henk G. Der Van Poel; Peter F. A. Mulders; Gosse O. N. Oosterhof; Jack A. Schalken; Frans M. J. Debruyne; H. Ewout Schaafsma; Jan C. M. Hendriks
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 745 KB
- Volume
- 72
- Category
- Article
- ISSN
- 0008-543X
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## BACKGROUND. A multiple sampling study was performed on 124 specimens of renal cell carcinomas to analyze the consistency and reliability of DNA measurements. The authors investigated intratumoral DNA heterogeneity and its role as a adverse prognostic factor for disease progression. ## METHODS
## Abstract Antiangiogenic therapies are used for advanced clearβcell renal carcinomas (cRCC), but without curative possibilities, underlining the need for new therapeutic targets. Adrenomedullin (AM), a multifunctional peptide, is highly expressed in several tumors and plays an important role in a
The present work aims to refine prognosis in cases of renal cell carcinoma (RCC) by integrating a variety of parameters with the prognostic information provided by histopathological grading and clinical staging, carried out on a series of 97 RCCs. To this end, Feulgen-stained RCC cell nuclei were ch