cant independent prognostic value. Because IGF-I and Insulinlike growth factor I (IGF-I) is a single-polypep-IGFBP-3 were closely correlated, they contained almost tide chain with important anabolic and endocrine activithe same prognostic information. Inclusion of IGF-I gave ties. The liver is the major source of IGF-I and its binding these results: IGF-I (P Γ΅ .03), alcohol intake (P Γ΅ .02), protein, IGFBP-3. Circulating concentrations of IGF-I coagulation factors 2, 7, and 10 (P Γ΅ .01), creatinine (P and IGFBP-3 are decreased in patients with chronic Γ΅ .001), and IgM (P Γ΅ .01) contained independent progliver disease and correlate with the severity. The aim of nostic information. Inclusion of IGFBP-3 gave these rethis study was to assess the additional prognostic value sults: IGFBP-3 (P Γ΅ .02), alcohol intake (P Γ΅ .05), coagulaof IGF-I and IGFBP-3 in patients entered in a large tion factors 2, 7, 10 (P Γ΅ .01), creatinine (P Γ΅ .001), and multicenter study (EMALD). Three hundred thirty-IgM (P Γ΅ .02) were independent predictors of survival. seven patients with alcohol-induced liver disease were In conclusion, IGF-I or IGFBP-3 provide important addistudied in a randomized placebo-controlled trial of mational information on survival in patients with alcohollotilate with a mean follow-up period of 569 days (range, induced liver disease. (HEPATOLOGY 1996;23:1073-1078.
) 7-1,544). A multivariate Cox regression analysis of pertinent clinical and biochemical variables showed a significant independent prognostic value of years of alcohol
Insulinlike growth factor I (IGF-I) is a single-chained intake, coagulation factors 2, 7, and 10, alkaline phosphapolypeptide with important anabolic actions on protein, tases, serum creatinine, and immunoglobulin (Ig) M. carbohydrate, and lipid metabolism. 1-3 IGF-I is bound When IGF-I or IGFBP-3 were added into this model, a in the circulation to a complex system of at least six Cox regression analysis showed that either had a signifibinding proteins; IGF-binding protein-3 (IGFBP-3) is the most abundant, playing a major role in determining Abbreviations: IGF-I, insulinlike growth factor I; IGFBP-3, insulinlike the total concentration of IGF-I in the circulation. 3,4 growth factor-binding protein 3; B/B0, bound/free ratio; Ig, immunoglobulin.