Prognostic value of histopathologic parameters of esophageal squamous cell carcinoma

✍ Scribed by Mario Sarbia; Fernando Bittinger; Rainer Porschen; Philipp Dutkowski; Reinhart Willers; Helmut E. Gabbert

• Publisher: John Wiley and Sons
• Year: 1995
• Tongue: English
• Weight: 534 KB
• Volume: 76
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/1097-0142(19950915)76:6<922::aid-cncr2820760603>3.0.co;2-q

✦ Synopsis

Background. The grading of squamous cell carcinoma (SCC) of the esophagus as proposed by the World Health Organization (WHO) has not yet proved to be prognostically significant. Therefore, the prognostic impact of various histologic parameters was investigated and compared with that of the WHO grading.

Methods. Hematoxylin and eosin-stained tumor samples from 138 patients with SCC of the esophagus who underwent potentially curative resection (no residual tumor or distant metastases) were evaluated for the following histologic parameters: degree of keratinization, nuclear polymorphism, pattern of invasion, mitotic activity, and inflammatory response. The prognostic impact of these parameters was analyzed by univariate and multivariate survival analyses.

Results. In the univariate analysis, the inflammatory response ( P = 0.0006), pattern of invasion (P = 0.0011), and nuclear polymorphism (P = 0.0161) were the only parameters that correlated with survival. However, in a multivariate survival analysis including these parameters, only pattern of invasion ( P = 0 . 0 0 ~0 ) and inflammatory response (P = 0.0076) were prognosticallly significant. Based on these results, a new prognostic score system was defined that correlated significantly with survival in the univariate survival analysis ( P = 0.0002).

In contrast, the WHO histologic grade was not prognostically significant. In the multivariate Cox regression analysis, the new prognostic score system proved to be an independent prognostic parameter (P = 0.0062), ranking next to pT classification ( P = 0.0001) and pN classification ( P = 0.0014).