Prognostic value of deoxyribonucleic acid content in prostate cancer: A review of current results

✍ Scribed by Jan Adolfsson

• Publisher: John Wiley and Sons
• Year: 1994
• Tongue: French
• Weight: 726 KB
• Volume: 58
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910580212

✦ Synopsis

A total of I I 5 articles on prostate cancer were reviewed for data on the prognostic value of D N A content in the tumor cells. In 44 series, data pertinent to this review were found. There was no consensus in the literature with respect to methods of analysis of DNA content or definitions of subclasses of D N A content such as categories of ploidy. The D N A content of prostate cancer cells was strongly related to tumor grade and stage. When analyzed as a single parameter in univariate analyses, the D N A content had a prognostic value with respect to overall or disease-specific survival. In multivariate analyses the additional prognostic value of the D N A content was less convincing when analysed with tumor grade and stage. The prognostic data from univariate and multivariate analyses available in the literature were mainly derived from patients with advanced disease and data on localized, potentially curable disease were scanty and conflicting. c 1994 U ' l / t Y l , 1 5 ~, In1

Univariate analysis in patient series restricted to specific tumor stages A univariate analysis in patients with a specific tumor stage was performed in 9 studies (Table 11). A statistically prognostic significance of the DNA content, when analyzed as a single