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Prognostic value of CD44 splice variants in human stage III cervical cancer

✍ Scribed by C. Kainz; P. Kohlberger; C. Tempfer; G. Sliutz; G. Gitsch; A. Reinthaller; G. Breitenecker

Book ID: 116166466
Publisher: Elsevier Science
Year: 1995
Tongue: English
Weight: 401 KB
Volume: 31
Category: Article
ISSN: 0959-8049
DOI: 10.1016/0959-8049(95)00353-k

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CD44 is a family of cell surface transmembrane glycoproteins members which differ in the extracellular part by sequences derived by alternative splicing of 10 variant exons (v1-v10). CD44 proteins containing such variant sequences have been implicated in tumor metastasis formation. Here, we have eva

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In the present study, the expression and prognostic role of the CD44 splicing variants v5 and v6 were immunohistochemically investigated in 418 curatively resected gastric carcinomas. CD44v5 was expressed in 65•3 per cent (n=273) and CD44v6 in 77•0 per cent (n=322) of the tumours. Whereas the expres

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