Prognostic value of BHCG and local tumor invasion in stage I seminoma of the testis

✍ Scribed by Schwartz, Bradley F.; Auman, Richard; Peretsman, Samuel J.; Moul, Judd W.; Deshon, George E.; Hernandez, Javier; Rozanski, Thomas A.; Thrasher, J. Brantley

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 255 KB
• Volume: 61
• Category: Article
• ISSN: 0022-4790
• DOI: 10.1002/(sici)1096-9098(199602)61:2<131::aid-jso7>3.0.co;2-d

✦ Synopsis

Approximately 10-15% of patients with stage I pure seminoma of the testis have an elevated preorchiectomy serum beta human chorionic gonadotropin level [ l a ] . The prognostic significance of this elevation is unknown. We performed a multi-institutional retrospective review of 332 men with stage I pure seminoma of the testis and evaluated the prognostic significance of this elevation and the prognostic value of local invasion of the primary tumor. Twenty-five of 191 evaluable patients (13%) had elevated preorchiectomy beta human chorionic gonadotropin. All normalized postoperatively and are alive without evidence of disease with a median follow-up of 50 months (range 1-124 mo). Of 191 patients, 190 (99.5%) are alive and free of disease. One patient underwent salvage chemotherapy for a chest recurrence, and he is alive and free of disease at 7 2 months. We conclude that elevated preorchiectomy serum beta human chorionic gonadotropin level and local invasion of the primary tumor do not portend a poor prognosis in patients with clinical stage I pure seminoma of the testis. o 1996 WiIey-Liss, Inc.