Prognostic significance of peritoneal tumour cells identified at surgery for colorectal cancer

✍ Scribed by H. Katoh; K. Yamashita; T. Sato; H. Ozawa; T. Nakamura; Professor M. Watanabe

• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 161 KB
• Volume: 96
• Category: Article
• ISSN: 0007-1323
• DOI: 10.1002/bjs.6622

✦ Synopsis

Abstract

Background

The prognostic significance of intraperitoneal tumour cells (IPCs) in colorectal cancer is not clear. This study aimed to determine whether detection of IPCs could be used a prognostic marker for selecting patients at high risk of recurrence.

Methods

The study included 226 patients with colorectal cancer who underwent elective resection. Clinical variables, including the presence of IPCs, were analysed for their prognostic significance.

Results

Thirty-three patients (14·6 per cent) were positive for IPCs. Univariable analysis indicated that the presence of IPCs was a significant prognostic factor in patients with stage III colorectal cancer; the 5-year disease-specific survival rate was 14 per cent in IPC-positive patients versus 79 per cent in those without IPCs (P < 0·001). Multivariable analysis showed that IPC positivity was the most robust prognostic factor in stage III disease (hazard ratio 2·2; P = 0·003), whereas nodal category (N1 or N2) showed no significant association with prognosis. In addition, IPCs were associated with haematogenous recurrence (P = 0·004) rather than peritoneal or local recurrence (P = 0·077) in patients with stage III disease.

Conclusion

The presence of IPCs is a significant prognostic factor in patients with stage III colorectal cancer.