Prognostic significance of p53 nuclear and cytoplasmic overexpression in right and left colorectal adenocarcinomas
✍ Scribed by X.F. Sun; J.M. Carstensen; H. Zhang; G. Arbman; B. Nordenskjöld
- Book ID
- 116167980
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 552 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0959-8049
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
The products of bcl-2 and p53 genes are involved in the regulation of apoptosis and proliferation and have been associated with prognosis in several malignancies, including colorectal adenocarcinoma. Although 2 European studies have reported a prognostic significance of Bcl-2 expression in colorecta
## Abstract ## Background Cyclooxygenase (COX)‐2 is believed to be an important enzyme related to the pathogenesis of colorectal cancer (CRC). p53 has been reported to be a negative regulator of COX‐2 expression in in vitro studies. The aim of this study was to investigate COX‐2 expression and its
## BACKGROUND. Although several studies have been conducted to examine the role of p53 genetic abnormalities and their prognostic value in colorectal carcinoma, the incidence of nuclear accumulation of p53 and the prognostic importance of nuclear accumulation of p53 in African-American and white p