Prognostic significance of p53 and matrix metalloproteinase-9 expression in follicular lymphoma
β Scribed by Heli Pennanen; Outi Kuittinen; Ylermi Soini; Taina Turpeenniemi-Hujanen
- Book ID
- 114794442
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 373 KB
- Volume
- 81
- Category
- Article
- ISSN
- 0902-4441
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## Abstract ## BACKGROUND NonβHodgkin lymphoma (NHL) represents a heterogeneous group of tumors that vary with regard to their biologic aggressiveness and clinical course. In in vitro studies, matrix metalloproteinase 9 (MMP9) was reportedly expressed by human NHL cells and elevated levels of MMP9
Recent studies have shown bcl-2 to be regulated by p53. Other studies have suggested an inverse relationship between p53 and bcl-2 protein expression in breast and colonic cancers and in a variety of subtypes of non-Hodgkin's lymphoma. This study investigates the relationship between bcl-2 and p53 p